Krystexxa là một enzyme giúp giảm axit uric khi chuyển hoá nó thành một hoá chất vô hại bài tiết qua nước tiểu. Các phản ứng phụ gồm buồn nôn, chỗ chích bầm tím, ngứa khoang mũi, táo bón, đau ngực, ói mửa. Krystexxa do hãng Savient Pharmaceuticals bào chế, tiêm cho bệnh nhân hai tuần một lần. FDA yêu cầu bác sĩ xem hướng dẫn trước khi tư vấn thuốc cho bệnh nhân.
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