Tin tức và sự kiện

Virus HIV có thể trốn trong tủy xương

Cập nhật lúc: 8:18:53 SA - 10/03/2010

 

(Dân trí) - Theo một nghiên cứu mới nhất tại Mỹ, virus gây bệnh AIDS có thể ẩn mình trong tủy xương, trốn tránh sự tấn công của các loại thuốc điều trị và “tái xuất” khi cơ thể hết thuốc. Và phát hiện quan trọng này sẽ mở ra hướng điều trị tốt hơn cho người bệnh.
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Những tế bào máu bị virus HIV hủy hoại (màu trắng)

 

Phát hiện sự trốn tránh và tái xuất này được xem là bước đầu tiên nhưng được coi là nghiên cứu đáng giá hàng đầu trong nhiều năm qua. TS. Kathleen Collin, ĐH Michigan (Mỹ) và các cộng sự của bà công bố kết quả nghiên cứu trên tạp chí Nature Medicine rằng virus HIV có thể trú ẩn rất lâu trong tế bào tủy xương mà những tế bào này sẽ trở thành tế bào máu.
 
“Virus này nằm im trong tế bào tủy xương nhưng khi các tế bào khởi thủy này phát triển thành tế bào máu, chúng sẽ tái xuất và gây ra tình trạng viêm nhiễm mới. Virus này sẽ tiêu diệt các tế bào máu và “nhảy” sang các tế bào lành khác, tiếp tục “tác quái””, bà Collin giải thích.
 
Trong những năm gần đây, thuốc điều trị AIDS đã giúp giảm tỉ lệ tử vong rõ nét nhưng bệnh nhân cần uống thuốc suốt đời hoặc sẽ bị tái phát bệnh. Có một tình trạng là chỉ khi uống thuốc, virus mới bị khống chế, còn ngừng thuốc là bệnh lại trỗi dậy. Thủ phạm của tình trạng này có thể là tế bào máu non có tên macrophages. Một loại tế bào khác có liên quan là tế bào T (bạch cầu) và nghiên cứu đã tập trung vào những tế bào này.
 
Mặc dù những phát hiện trên không thể giải thích cho sự gia tăng của virus HIV trong tất cả các trường hợp nhưng nó cho thấy có những yếu tố cần phải lưu tâm và điều này đã khiến bà Collin tập trung nghiên cứu tế bào tạo máu. Và những phát hiện này đặc biệt quan trọng vì nó cho thấy vì sao bệnh nhân sẽ phải tiếp tục uống thuốc sau khi sự viêm nhiễm tưởng như đã chấm dứt.
 
“Tôi không biết có bao nhiêu người nhận ra rằng mặc dù thuốc điều trị AIDS giúp giảm tỉ lệ tử vong nhưng vẫn còn rất xa để đạt được cái đích là chữa khỏi bệnh. Điều này đồng nghĩa rằng chỉ cần ngừng thuốc là năm tháng cuộc đời sẽ bị rút ngắn nhanh chóng”, bà Collin nói.
 
Nghiên cứu do Viện Sức khỏe Mỹ, Quỹ Burroughs Wellcome, ĐH Michigan, Hội ái hữu Rackham Predoctoral, Quỹ Khoa học Mỹ và Hội ái hữu Bernard Mass tài trợ.
 
 
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